Sezary syndrome: diagnosis and management

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Mycosis fungoides and Sezary syndrome.

YCOSIS FUNGOIDES (MF) is an uncommon, indoM lent T-cell lymphoma first described by Alibert' in the early 1800s. It primarily involves the skin at early stages of the disease, with plaques being the typical feature. After a variable period of time, it may progress with development of cutaneous tumors and spread to visceral sites and lymph nodes (LNs).* SBzary syndrome (SS) is an erythrodermic v...

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AIM The aim of this paper was to present diagnostic methods helping in the recognition of mycosis fungoides (MF) and Sezary syndrome (SS). BACKGROUND Mycosis fungoides is the most common form of primary cutaneous T-cell lymphomas. It is characterized by a distinctive long-term course and malignant T-cell proliferation. MF diagnosis is not easy, mainly due to the atypical clinical presentation...

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Sézary syndrome (SS) is an aggressive cutaneous T-cell lymphoma (CTCL) of unknown etiology in which malignant cells circulate in the peripheral blood. To identify viral elements, gene fusions, and gene expression patterns associated with this lymphoma, flow cytometry was used to obtain matched pure populations of malignant Sézary cells (SCs) versus nonmalignant CD4(+) T cells from 3 patients fo...

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ژورنال

عنوان ژورنال: The Journal of the Royal College of Physicians of Edinburgh

سال: 2012

ISSN: 1478-2715,2042-8189

DOI: 10.4997/jrcpe.2012.408